Polina Osetinskaya began to play the piano at the age of five, while at the age of six she gave her first recital at the Vilnius Philharmonic and at the age of eight she made her debut with the Lithuanian Chamber Orchestra under Saulius Sondeckis.
Graduated from the Middle Special School of Music of the St Petersburg State Rimsky-Korsakov Conservatoire and the St Petersburg Conservatoire itself (class of Marina Wolf). Trained at the Moscow State Tchaikovsky Conservatoire under Vera Gornostaeva.
Has appeared with the Tokyo Philharmonic Orchestra, the Academic Symphony Orchestra of the St Petersburg Philharmonic (Honoured Ensemble of Russia), the State Academic Svetlanov Symphony Orchestra, the Moscow Virtuosi, the New Russia orchestra and the European Sinfonietta among other ensembles. Osetinskaya's stage partners have included the conductors Saulius Sondeckis, Laurent Petitgirard, Vassily Sinaisky, Andrey Boreyko, Gerd Albrecht, Yan Pascal Tortelier, Thomas Sanderling, Tugan Sokhiev and Alexander Sladkovsky.
Has appeared at the Great and Small Halls of the Moscow Conservatoire and the St Petersburg Philharmonic, Vienna's Musikverein, the Concert Hall of the Mariinsky Theatre, various venues in Warsaw, San Francisco and Brussels as well as at the festivals December Evenings, Crescendo, Stars of the White Nights and Mainly Mozart among others.
Recipient of the Little Triumph award. In 2008 she wrote her autobiography Farewell, Sadness! which became a bestseller. Frequently performs music by composers of the post-avant-garde movement, among them Valentin Silvestrov, Leonid Desyatnikov, Vladimir Martynov, Georgs Pelēcis and Pavel Karmanov.
Engagements for the 2017–2018 season include a tour to Israel (Jerusalem, Tel Aviv, Haifa and Beersheba), concerts at the St Petersburg State Philharmonic and the Moscow State Philharmonic and appearances in Limassol, Tobolsk, Ryazan and Obninsk among other cities.
The pianist's records have been released on the Sony Music, Naxos, Bel Air and Quartz labels.